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These findings suggest that the weight lossalleviation of lipotoxicityimprovement of hyperandrogenism cascade exhibits strong consistency at the RCT level, although IR markers (e.g., HOMA-IR) do not necessarily improve synchronously (79)

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Across multiple experimental modelsincluding Parkinsons disease, Alzheimers disease, and cerebral ischemia-reperfusion injuryriboflavin supplementation has demonstrated consistent neuroprotective effects, reflected in reduced oxidative burden and preservation of neuronal integrity ( Mechanistically, riboflavin deficiency leads to diminished glutathione reductase activity, reducing the GSH/GSSG ratio and compromising redox buffering